Aside from the random crazy person, I'd say most of us know that our QBs next season will be Losman and Holcomb, and the #1 priority this offseason is improving the O-Line. As it stands, I'd rather see the Bills spend 2 out of the their top 3 picks on O-Lineman and pick up two new starters in free agenct (One at Tackle and one at Guard).
As it stands right now, I'd love to see the Bills get Jeff Backus and Stephen Neal in FA. Plug in Backus at LT, put Neal in at LG. Preston gets promoted to Center after Teague leaves, and using the draft below, have O'Callaghan and Peters fight it out in camp for the RT spot and have Lutui as good depth and Villarial's future replacement at RG. I'd be a damn happy camper to see that O-Line.