Just my opinion, but if I were the Bills' GM and inclined to trade up, it would be for someone like OT Russell Okung or DT Ndamukong Suh. I would get stronger up front FIRST before I did anything. The Jets took this approach, drafting D'Brickashaw Ferguson, then Nick Mangold and adding Alan Faneca in free agency. They did not keep using high pick after high pick on skill players and leave the lines to the wolves.
Then again, maybe there's some great second round gems to be had for the lines, after we get a QB first. Oops, we said trade up for a QB, right? There goes that 2nd rounder and, depending on the target and how far you have to move to get 'em, there may go a future high pick as well.
Well, there's always the 4th round and beyond.