I'm not sure how the new rule plays into IRing players. Suspended players shouldn't count against the 53 man roster as far as I know. So realistically the Bills should have 55 with today's cuts or more if we did IR somebody.
I can see them trading one of them similar to the year we moved Marshall Newhouse and Russ Bodine. Maybe we move Carter for a CB like Clark Phillips III
or we could have drafted Josh Myers (drafted 1 pick before Creed) who was 46th ranked Center last season according to PFF or even WR Amari Rodgers (drafted 4 picks before Nico) who was playing in the UFL. It's fun to play what if but sometimes the what if isn't always better.
If Asante Samuel Jr is that good then he would have been signed by now, he's probably hurt and it's a risky injury that people don't want to give him top dollar for it. Not sure he's worth the risk.