Jaguars (3-7) at Bills (3-7): 1 p.m. ET, CBS
Point spread: JAX -3 | Matchup quality: 22.0 (of 100)
Mike DiRocco's pick: Leonard Fournette has had 59 touches in his first two games back from a hamstring injury, and there's no reason to expect his workload to decrease significantly in Week 12. The Jaguars won the playoff matchup in January by being conservative on offense and relying on the defense. That will be the strategy Sunday, especially if Josh Allen is back for Buffalo. They'll try to force the rookie quarterback into a couple of mistakes, grab a few turnovers and keep LeSean McCoy from breaking off any big runs. Do that, and they'll be able to snap their six-game losing streak. Jaguars 13, Bills 7
Mike Rodak's pick: The last time Blake Bortles faced the Bills' defense, he passed for 87 yards and led the Jaguars to a 10-3 AFC wild-card playoff win. In predicting this game, the question is less about whether Bortles can beat the Bills' defense and more about whether the Bills' offense can prove the 41 points it hung on the Jets in a Week 10 victory was not a fluke. In a game in which one touchdown could decide the result, I will give the edge to a Jacksonville defense that has allowed a 56 percent conversion rate in the red zone compared to a 67.7 percent rate allowed by Buffalo. Jaguars 14, Bills 10
FPI win projection: BUF, 51.7 percent. There might not be a lot of offense to be found in this game. Both teams rank in the top 10 in defensive efficiency this season and in the bottom five in offensive efficiency, according to FPI.