June 25/26, 1876
Lt Colonel George A. Custer's blatant "lack of respect" for the Lakota, Northern Cheyenne, and Arapaho, resulted in the annihilation of 5 of his 7th Cavalry companies including Custer himself, his two brothers, a nephew, and a brother in law, during the Bloody Battle of the Little Big Horn, otherwise known as "Custers Last Stand" (268 US casualties)