I do think this is the week where the Bills injuries catch up to them. You're asking Baylon Spector, Dorian Williams and Cam Lewis with the slowest set of safeties in the NFL to contain Lamar Jackson, Mark Andrews, Isiah Likely and Derrick Henry? Nah man that ain't it. Not even McDermott witchcraft is going to have consistent success here.
For the Bills to win this way, I think they need to goto a grind offense to protect their defense, and then defensively just be opportunistic, and hold them to FGs in the Red Zone. If they Bills want to have a truly good game defensively then Ed Oliver, AJE, DJ, Austin Johnson, and Groot are going to have to have elite games on 1st and 2nd down, so they can unleash Von on 3rd and long.
Offensively Spencer Brown is gonna have his biggest challenge yet with Odafe Oweh who looks like he's taken the leap. This is a DE with legit 4.3 40 speed who's currently got an 84.8 grade on PFF. If Brown can handle him on his own that's gonna be huge - but good chance he's gonna need help