Good post and topic. I'm thankful to Ralph C Wilson for founding the Buffalo Bills, ensuring they stayed in Buffalo after his death, and being one of the original owners who helped form today's NFL. The Buffalo Bills are a part of who I am, and am grateful to Ralph.
I think Ralph loved the Bills, western NY, and was well intentioned. I have no doubt he wanted a winner. My opinion of where he went wrong was inserting himself in the football operations which ultimately lead to the firing of Bill Polian. Granted, Polian had a strong personality from what I understand, but had they got along better, who knows how history would have changed. It's possible that Ralph had a hard time adjusting to a model where the owner stayed hands off in the background and let a President/GM run the show. When he realized this, Ralph eventually ended up making a bad hire in Tom Donahoe and things didn't start improving until years later.
It will be interesting to read everyones posts on this topic.