I used to answer the question by suggesting that unless the Bills win the Superbowl, they retain the "loser" tag because of the 4 Superbowls.
Now, they've been bad for so long, I would take another string of losing in the playoffs just to be relevant again. So I'd really LOVE to see the Bills spike up and be GREAT for 1 year (SB), but I'd take consistently good.