I'm not going to say it's impossible but QB is the most important position and Offensive line is the most important unit and the Bills are unproven at those positions to say the least- the NFL is a passing league, I mean Chris Johnson had what 2500+ total yards and the Titians didn't make the playoffs, the Bills are unproven at QB, OTs, #2WR, and TE. The defense has a little more talent but most of them are going to be rookies in the 3-4.
What I wonder is has any team made it to the playoffs on interceptions and the return game.