I have no idea how the Bills or Sabres will turn out.
When he bought the Sabres he took off the financial handcuffs, and Regier went nuts throwing money around (Leino? Seriously?). They have a complete rebuild going on now, and only time will tell.
The Bills appear on paper to be much improved from the previous 14 years. I doubt he'd make any changes if progress is being made. Much like the Sabres, I don't think money will be an issue, he'll allow them the room they need to maneuver.
Aside from giving people the tools they need to do their job, he can't win the games himself. The players and coaches need to do their part.