The Bills have a better QB, better RB situation, even WRs, and a better TE.
On paper the D is a push but will give LA the edge given absence of White.
With a better QB and RB and TE, and push on D, I think you should win 80 percent of the time. The Bills may be favored, but this is a bit of a revenge game of sorts, almost the SB that should have been. I don’t think the players are taking this as an “inferior opponent”. Also, a good team wins games when favored.
Finally, the Bills have been great in prime time.