Can the Bills lose? Of course...it's the NFL, the ultimate 'week to week' league. But for those worried about a loss or having 'a bad feeling', relax. If the Bills play up to their abilities, especially on offense, they win this contest. If not, they deserve to lose. Look at Tennessee to date. They are 3-0 against teams with a combined 3-9 record:
Week 1 (A): Beat the Broncos, 16-14, with a FG in the waning seconds of the game (0:17). Yes, Stephen Gostkowski was 0-3 prior to that so it shouldn't have been quite that close, but still. Denver is currently 1-3.
Week 2 (H): Beat the Jaguars, 33-30, after making a FG with 1:36 to go...this after allowing the Jags to score two 4th quarter TDs to tie the game. Jacksonville is currently 1-3.
Week 3 (A): Beat the Vikings, 31-30, after making a FG with 1:44 to go and trailing for much of the game. Minnesota is currently 1-3 and, arguably, the only decent opponent Tennessee has faced.
This is not the same team that made the AFC Championship Game last year...at least not yet. They have been brutal on D. If they let the Jags and Vikes both hang 30 on them even with Derrick Henry to 'control the clock', the Bills can, too. If the Bills lose, it's because they either come out flat due to all of the changes/distractions (don't think McDermott will let that happen) or they beat themselves. Given everything leading up to this game, and the players the Titans will be missing, Buffalo should win, IMO. They are road favorites against an unbeaten team for a reason.
GO BILLS!!!