My prediction is any Pat who is even a little dinged up sits the majority, if not the entire, game.
The Pats won't show anything great, but might show a few out of character plays to try and force playoff opponents to waste time preparing for them.
They won't want to get swept by the hapless Bills, particularly at home. So they will play good enough to win and not much more.
I expect Spiller to have another good game statistically, possibly > 100 yards if Gailey doesn't abandon the run at halftime.
I expect the passing game to look pedestrian again.
Pats by 10 or less.