ESPN's Tim Graham reported last week that the Bills may use a no-huddle offense this season. Not only was this also confirmed to me by a source close to the team, I was also told now that the team has a tight end they feel can be an important part of the passing game (rookie Shawn Nelson), they will look to use much more spread-formations in their base offensive sets, using three wide receivers, plus splitting Nelson out as a 4th receiver, and only using one running back in the backfield. The source said the Bills may do this even when they do not a run a no-huddle. The Bills had incorporated a fullback into their offensive gameplan more often the past two seasons. Running more 4 wide, 1 RB sets would obviously mean there wouldn't be a FB on the field as often.
http://www.salsports.com/NFLMayUpdate.htm