If you want to completely be away from drunken fools, stay out of Orchard Park on Bills game day.
That being said, if you want to avoid most of it the clubs are probably your best bet. I can't see the Bills or Jets being great this year so you'll probably be able to pick some tickets up for a pretty reasonable price once the game is a little bit closer, time-wise.
Truthfully there isn't a bad seat in the place. I often sit in 333 which has a fair number of longtime season ticket holders who are pretty well behaved. YMMV