‘The 49ers come to Buffalo banged up. Defensive end Nick Bosa and left tackle Trent Williams are just two of the several notable names who won’t play. Quarterback Brock Purdy is ailing, but will start. They’re 5-6 and have lost two in a row. They know it’s going to be cold and could be snowy. If the Bills can jump on them early, 49ers players may mentally check out and just want to get back to sunny California to lick their wounds.’