‘There is cause for concern with this game. Namely, the 49ers, who entered the year with Super Bowl aspirations, are a desperate team in need of a victory to keep their hopes of qualifying for the playoffs by way of winning the NFC West alive. The Bills remain squarely in the running for the AFC’s No. 1 seed, so there is plenty to play for, even with a fifth straight AFC East title a foregone conclusion. Buffalo is unbeaten under Sean McDermott following the bye week. The 49ers are too banged up and are going to be too travel fatigued to leave Orchard Park with a victory. Bills, 30-20.’