‘Key Matchup: Buffalo’s running game against Detroit’s defense. Bills RB Devin Singletary ran for a season-high 86 yards, the same total rookie RB James Cook had for his best game on the ground in the win over Cleveland. That production took pressure off QB Josh Allen. The Lions have been shaky against the run, but they did limit Giants RB Saquon Barkley to a season-low 22 yards on 15 carries.’