’49ers wide receivers Deebo Samuel and Brandon Aiyuk will both be on the field for only the fifth time this season and the first since October 25. Since then, in the two games Aiyuk played without Samuel, he totaled 15 catches for 166 yards and two touchdowns. In the one game Samuel played without Aiyuk, he grabbed 11 passes for 133 yards. Now, the Bills will have to figure out a way to cover both of them, including as runners. Between the two of them, Samuel and Aiyuk have carried the ball 11 times for 75 yards and 2 TDs on the season.’