'There are a handful of players the Bills simply cannot afford to lose this season. Tight end Charles Clay is on that list, but unfortunately for the Bills, that’s what happened. Clay suffered a left knee injury late in the first quarter after being tackled by Bengals safety Shawn Williams at the end of a 24-yard gain. If Clay’s injury is long term — and seeing him carted off wasn’t a good sign — the Bills will be down to Nick O’Leary, Logan Thomas and little-used Khari Lee at tight end. That’s trouble.'