'In addition to their AFC East opponents, the Bills will face the AFC West (visiting the Chargers and Chiefs while hosting the Broncos and Raiders) and NFC South (visiting the Falcons and Panthers while hosting the Buccaneers and Saints) teams. Buffalo also will host Indianapolis and visit Cincinnati by way of those teams finishing in third place − like the Bills did in the AFC East − in the AFC South and AFC North, respectively. The Colts have the "easiest" schedule, with an opponent winning percentage of .424.'