'The Niners have one of the weaker offensive lines in the NFL, and it was outplayed by the Bills’ defensive front. San Francisco running backs carried 20 times for just 67 yards, a 3.35-yard average. Niners right guard Joshua Garnett is a rookie first-round draft pick who was making his first start. Center Daniel Kilgore has made 16 starts in six years. Left guard Zane Beadles is a former big-ticket free agent who washed out in Jacksonville and who struggles in pass protection. The middle three got no push against the Bills.'