‘The Bills don’t match up with the 49ers particularly well. With the run defense being attacked as much as they were last week, San Francisco will likely follow that model in the upcoming contest. Their powerful and road-grading offensive line enables them to run the ball as efficiently as they do. That, combined with the likelihood of the 49ers defense to force turnovers on a turnover-prone Bills offense, leads me to believe San Francisco will come away victorious. Meanwhile the Bills are likely destined for a 2-3 record, and a loss to start off their most critical five-game stretch of the season.’