‘First, the Bills have still-unproven quarterback J.P. Losman, who has thrown 15 touchdown passes and 15 interceptions in his three-year career, and he’s been sacked 26 times this season, the third most in the NFL. Establishing the run game would take pressure off Losman. Second, the Colts’ run defense has been abhorrent. It ranks last in the NFL, allowing 165.4 yards a game.’