Bills open with Jets and close with Bungles. No ESPN or ABC MNF night games it appears.
| Sep 8 | NY JETS | 1:00 PM |
| Sep 15 | at Minnesota | 4:15 PM |
| Sep 22 | at Denver | 4:05 PM |
| Sep 29 | CHICAGO | 1:00 PM |
| Oct 6 | OAKLAND | 1:00 PM |
| Oct 13 | at Houston | 1:00 PM |
| Oct 20 | at Miami | 1:00 PM |
| Oct 27 | DETROIT | 1:00 PM |
| Nov 3 | NEW ENGLAND | 1:00 PM |
| Week 10 | OPEN DATE | |
| Nov 17 | at Kansas City | 1:00 PM |
| Nov 24 | at NY Jets | 1:00 PM |
| Dec 1 | MIAMI | 1:00 PM |
| Dec 8 | at New England | 1:00 PM |
| Dec 15 | SAN DIEGO | 1:00 PM |
| Dec 22 | at Green Bay | 1:00 PM |
| Dec 29 | CINCINNATI | 1:00 PM |