‘Even when the San Francisco 49ers were struggling to escape the salary-cap jail in which the Buffalo Bills landed last spring, their offense could cause problems for anybody. But San Francisco is 8-2 and on top of the NFC West two years after crashing to 4-12 in 1999 because the 49ers defense is finally catching up. That can only be bad news for the hapless Buffalo Bills, who head into Sunday night’s nationally televised game still reeling from their collapse last week against Miami. None of San Francisco’s first seven wins were by more than a 10-point margin, with five coming by six or less — three in overtime. But last week, playing on the road, the 49ers harassed Indianapolis quarterback Peyton Manning into throwing four interceptions. San Francisco’s 40-21 win sent Colts coach Jim Mora into one of his post-game tirades and likely ended Indy’s realistic playoff hopes. Buffalo, of course, said goodbye to such hopes well before Halloween. While plenty of numbers hint at reasons for the Bills’ 1-9 record, the most significant is minus-12. That’s Buffalo’s giveaway/takeaway ratio, and it ties the Bills with Indy, Miami and Minnesota at the bottom of the National Football League.’